ParkinsonCanadaV1, Main, Exploration, bibRecord, 001E84

Phactr2 and Parkinson's disease

Identifieur interne : 001E84 ( Main/Exploration ); précédent : 001E83; suivant : 001E85

Phactr2 and Parkinson's disease

Auteurs : Christian Wider [États-Unis] ; Sarah J. Lincoln [États-Unis] ; Michael G. Heckman [États-Unis] ; Nancy N. Diehl [États-Unis] ; Jeremy T. Stone [États-Unis] ; Kristoffer Haugarvoll [États-Unis, Norvège] ; Jan O. Aasly [Norvège] ; J. Mark Gibson [Irlande (pays)] ; Timothy Lynch [Irlande (pays)] ; Alex Rajput [Canada] ; Michele L. Rajput ; Ryan J. Uitti [États-Unis] ; Zbigniew K. Wszolek [États-Unis] ; Matthew J. Farrer [États-Unis] ; Owen A. Ross [États-Unis]

Source :

Neuroscience letters [ 0304-3940 ] ; 2009.

RBID : PMC:2684848

Descripteurs français

Wicri :
- geographic : Canada, Norvège, États-Unis.

English descriptors

KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Canada (epidemiology), Case-Control Studies, Female, Gene Frequency, Genome-Wide Association Study, Genotype, Humans, Ireland (epidemiology), Male, Microfilament Proteins (genetics), Middle Aged, Nerve Tissue Proteins (genetics), Norway (epidemiology), Parkinson Disease (epidemiology), Parkinson Disease (genetics), Polymorphism, Single Nucleotide, Risk Factors, United States (epidemiology), Young Adult.
MESH :
- chemical , genetics : Microfilament Proteins, Nerve Tissue Proteins.
- geographic , epidemiology : Canada, Ireland, Norway, United States.
- epidemiology : Parkinson Disease.
- genetics : Parkinson Disease.
- Adolescent, Adult, Aged, Aged, 80 and over, Case-Control Studies, Female, Gene Frequency, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors, Young Adult.

Abstract

Attempts at replicating the first genome-wide association study (GWAS) in Parkinson's disease (PD) have not successfully identified genetic risk factors. The present study reevaluates data from the GWAS and focuses on the SNP (rs11155313, located in the Phactr2 gene) with the lowest P-value in the Tier 2 patient-control series of the first PD GWAS. We employed four case-control series to examine the nominated SNP rs11155313 and identified association in US (OR: 1.39, P=0.032), Canadian (OR: 1.41, P=0.014) and Irish (OR: 1.44, P=0.034) patient-control series, but not in the Norwegian series (OR: 1.15, P=0.27). When combining all four series the observed trend was statistically significant (OR: 1.30, P<0.001). This study shows reappraisal of publicly available results of GWAS may help nominate new risk factors for PD.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684848

DOI: 10.1016/j.neulet.2009.02.009
PubMed: 19429005
PubMed Central: 2684848

Affiliations:

Canada, Irlande (pays), Norvège, États-Unis
Floride, Trøndelag
Trondheim

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p id="P1">Attempts at replicating the first genome-wide association study (GWAS) in Parkinson's disease (PD) have not successfully identified genetic risk factors. The present study reevaluates data from the GWAS and focuses on the SNP (rs11155313, located in the <italic>Phactr2</italic>
 gene) with the lowest <italic>P</italic>
-value in the Tier 2 patient-control series of the first PD GWAS. We employed four case-control series to examine the nominated SNP rs11155313 and identified association in US (OR: 1.39, <italic>P</italic>
=0.032), Canadian (OR: 1.41, <italic>P</italic>
=0.014) and Irish (OR: 1.44, <italic>P</italic>
=0.034) patient-control series, but not in the Norwegian series (OR: 1.15, <italic>P</italic>
=0.27). When combining all four series the observed trend was statistically significant (OR: 1.30, <italic>P</italic>
<0.001). This study shows reappraisal of publicly available results of GWAS may help nominate new risk factors for PD.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>Irlande (pays)</li>
<li>Norvège</li>
<li>États-Unis</li>
</country>
<region><li>Floride</li>
<li>Trøndelag</li>
</region>
<settlement><li>Trondheim</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Rajput, Michele L" sort="Rajput, Michele L" uniqKey="Rajput M" first="Michele L." last="Rajput">Michele L. Rajput</name>
</noCountry>
<country name="États-Unis"><region name="Floride"><name sortKey="Wider, Christian" sort="Wider, Christian" uniqKey="Wider C" first="Christian" last="Wider">Christian Wider</name>
</region>
<name sortKey="Diehl, Nancy N" sort="Diehl, Nancy N" uniqKey="Diehl N" first="Nancy N." last="Diehl">Nancy N. Diehl</name>
<name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name>
<name sortKey="Haugarvoll, Kristoffer" sort="Haugarvoll, Kristoffer" uniqKey="Haugarvoll K" first="Kristoffer" last="Haugarvoll">Kristoffer Haugarvoll</name>
<name sortKey="Heckman, Michael G" sort="Heckman, Michael G" uniqKey="Heckman M" first="Michael G." last="Heckman">Michael G. Heckman</name>
<name sortKey="Lincoln, Sarah J" sort="Lincoln, Sarah J" uniqKey="Lincoln S" first="Sarah J." last="Lincoln">Sarah J. Lincoln</name>
<name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name>
<name sortKey="Stone, Jeremy T" sort="Stone, Jeremy T" uniqKey="Stone J" first="Jeremy T." last="Stone">Jeremy T. Stone</name>
<name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name>
<name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name>
</country>
<country name="Norvège"><region name="Trøndelag"><name sortKey="Haugarvoll, Kristoffer" sort="Haugarvoll, Kristoffer" uniqKey="Haugarvoll K" first="Kristoffer" last="Haugarvoll">Kristoffer Haugarvoll</name>
</region>
<name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name>
</country>
<country name="Irlande (pays)"><noRegion><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name>
</noRegion>
<name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name>
</country>
<country name="Canada"><noRegion><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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La maladie de Parkinson au Canada (serveur d'exploration)

Phactr2 and Parkinson's disease

Phactr2 and Parkinson's disease

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	La maladie de Parkinson au Canada (serveur d'exploration)
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